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Update on DARE-19 Phase III trial for Farxiga in COVID-19

Date Time
Update on DARE-19 Phase III trial for Farxiga in COVID-19
AstraZeneca and Saint Luke’s Mid America Heart Institute today announced high-level results of the primary analysis from the DARE-19 Phase III trial assessing the potential of Farxiga (dapagliflozin) to treat patients hospitalised with COVID-19 who are at risk of developing serious complications.
The trial did not achieve statistical significance for the primary endpoint of prevention measuring organ dysfunction and all-cause mortality, and the primary endpoint of recovery measuring a change in clinical status (from early recovery to death), at 30 days.
DARE-19 was the first Phase III trial to evaluate the safety and efficacy of a sodium-glucose co-transporter-2 (SGLT2) inhibitor in patients hospitalised with COVID-19 who also have risk factors for developing serious complications, including hypertension (HTN), type-2 diabetes (T2D), atherosclerotic cardiovascular disease (ASCVD), heart failure ( ....

United Kingdom , Mikhailn Kosiborod , Company On Twitter Astrazeneca , Research At Saint Luke Health System , Saint Luke Mid America Heart Institute , Saint Luke , Mid America Heart Institute , Vice President , Health System , Executive Vice President , American College , Cardiology Scientific Sessions , Cardiovascular Health , Clinical Trials , Kidney Disease , Heart Failure , Heart Attack , ஒன்றுபட்டது கிஂக்டம் , ஆராய்ச்சி இல் துறவி லூக் ஆரோக்கியம் அமைப்பு , துறவி லூக் நடுவில் அமெரிக்கா இதயம் நிறுவனம் , துறவி லூக் , நடுவில் அமெரிக்கா இதயம் நிறுவனம் , துணை ப்ரெஸிடெஂட் , ஆரோக்கியம் அமைப்பு , நிர்வாகி துணை ப்ரெஸிடெஂட் , அமெரிக்கன் கல்லூரி ,

Another way "good" cholesterol is good: combatting inflammation

American Heart Association
Research Highlights:
The ability of HDL particles (commonly known as “good” cholesterol) to reduce inflammation in the cells that line blood vessels may help predict who is more likely to develop a heart attack or other serious heart-related event.
Gauging the anti-inflammatory capacity of HDL cholesterol may one day improve standard heart disease risk assessment.
The results may encourage greater attention to the function of HDL particles in addition to quantity of cholesterol within HDL in determining how to assess and reduce heart disease risk.
DALLAS, April 12, 2021 Testing how well “good” cholesterol particles reduce inflammation may help predict who is at heightened risk to develop cardiovascular disease caused by narrowed arteries, according to research published today in the American Heart Association’s flagship journal ....

United States , Robin Pf Dullaart , Stephanjl Bakker , Congzhuo Jia , Uwe Jf Tietge , Josephine Lc Anderson , Lung Foundation , American Heart Association , Netherlands Organization For Scientific Research , Karolinska Institute , Research Highlights , Framingham Risk Score , Netherlands Organization , Scientific Research , Swedish Heart Lung , Anti Inflammatory , Risk Assessment , Blood Vessels , Heart Disease , Disease Risk , Heart Attack , ஒன்றுபட்டது மாநிலங்களில் , நுரையீரல் அடித்தளம் , அமெரிக்கன் இதயம் சங்கம் , நெதர்லாந்து ஆர்கநைஸேஶந் க்கு அறிவியல் ஆராய்ச்சி , ஆராய்ச்சி சிறப்பம்சங்கள் ,

Changes in A1C May Be Related to Heart Disease

By Lydia Davis
Emerging evidence shows that variability in your A1C level may put you at a higher risk of stroke and heart disease.
A recent study revealed that variability in an individual’s A1C levels could be associated with their risk for developing diabetes-related complications, such as heart disease.
The study looked at the electronic health record data of almost 30,000 people with type 2 diabetes from 2013 to 2018 in southeast Louisiana. It included people who had at least four A1C measurements within two years of their diabetes diagnosis and no heart-related complications within that two-year period or the year before diagnosis. The sample’s demographics were 59% white and 41% African American. ....

United States , Lydia Davis , Time In Range Coalition , Tribe Foundation , Orange Coalition , Type 2 Diabetes , Heart Disease , Time In Range , ஒன்றுபட்டது மாநிலங்களில் , லிடியா டேவிஸ் , நேரம் இல் சரகம் கூட்டணி , பழங்குடி அடித்தளம் , சரகம் கூட்டணி , இதயம் நோய் , நேரம் இல் சரகம் ,

Substandard cardiac stents case: Cardiovascular issues left to inexperienced specialists: SC

Top Story
April 2, 2021
ISLAMABAD: The Supreme Court (SC) on Thursday issued notices to heads of the National and Provincial Health Commissions in substandard cardiac stents case. A three-member SC bench, comprising Chief Justice Gulzar Ahmed, Justice Ijazul Ahsan and Justice Sayed Mazahar Ali Akbar Naqvi, heard the case pertaining to imbedding substandard cardiac stents. The court also issued notices to all four provincial advocate generals. The court observed that cardiovascular issues were left to inexperienced specialists.
The court rejected the National Accountability Bureau (NAB) request to make NAB member of pricing committee.
At the outset of hearing, the court observed that substandard cardiac stents were being used across the country. The court sought implementation report on National Interventional Cardiology Board (NICB) recommendations. ....

Justice Ijazul Ahsan , Justice Gulzar Ahmed , Azhar Kiyani , National Accountability Bureau , Supreme Court , National Interventional Cardiology Board , Life Song Devices Pricing Committee , Provincial Health Commissions , Chief Justice Gulzar Ahmed , Justice Sayed Mazahar Ali Akbar Naqvi , Chairman Life Song Devices Pricing Committee , Ijazul Ahsan , அஜார் கியானி , தேசிய பொறுப்பு பணியகம் , உச்ச நீதிமன்றம் , தேசிய தலையீடு இருதயவியல் பலகை , வாழ்க்கை பாடல் சாதனங்கள் ப்ரைஸிஂக் குழு , மாகாண ஆரோக்கியம் கமிஷன்கள் , தலைவர் வாழ்க்கை பாடல் சாதனங்கள் ப்ரைஸிஂக் குழு ,

Substandard cardiac stents case: Cardiovascular issues left to inexperienced specialists, says SC

Top Story
April 2, 2021
ISLAMABAD: The Supreme Court (SC) on Thursday issued notices to heads of the national and provincial health commissions in substandard cardiac stents case.
A three-member SC bench, comprising Chief Justice Gulzar Ahmed, Justice Ijazul Ahsan and Justice Sayed Mazahar Ali Akbar Naqvi, heard the case pertaining to imbedding substandard cardiac stents. The court also issued notices to all four provincial advocate generals.
The court observed that cardiovascular issues were left to inexperienced specialists.
The court rejected the National Accountability Bureau (NAB) request to make NAB member of pricing committee.
At the outset of hearing, the court observed that substandard cardiac stents were being used across the country. The court sought implementation report on National Interventional Cardiology Board (NICB) recommendations. ....

Justice Ijazul Ahsan , Justice Gulzar Ahmed , Azhar Kiyani , National Accountability Bureau , Supreme Court , National Interventional Cardiology Board , Life Song Devices Pricing Committee , Chief Justice Gulzar Ahmed , Justice Sayed Mazahar Ali Akbar Naqvi , Chairman Life Song Devices Pricing Committee , Ijazul Ahsan , அஜார் கியானி , தேசிய பொறுப்பு பணியகம் , உச்ச நீதிமன்றம் , தேசிய தலையீடு இருதயவியல் பலகை , வாழ்க்கை பாடல் சாதனங்கள் ப்ரைஸிஂக் குழு , தலைவர் வாழ்க்கை பாடல் சாதனங்கள் ப்ரைஸிஂக் குழு ,